Luc Devereaux and Veronica Roberts continue their attempts to expose the Universal Soldier unit. But after a hostage situation mistakenly leaves Veronica a fugitive, the two escape the city and go into hiding. CIA Deputy Director Mentor and Dr. Walker are also in the middle of literally 'growing' a powerful new Universal Soldier clone of Luc's brother Eric to assassinate him and Veronica. Now it may leave Luc no chance to end it all.

Set before the events of the previous films. As group of strangers awaken with no memory to find they have been involuntarily placed in a maze containing deadly traps, a young man whose job is to watch over the Cube endeavors to rescue a woman trapped within.

Three stories - one each from the past, present, and future - about men in pursuit of eternity with their love. A conquistador in Mayan country searches for the tree of life to free his captive queen; a medical researcher, working with various trees, looks for a cure that will save his dying wife; a space traveler, traveling with an aged tree encapsulated within a bubble, moves toward a dying star that's wrapped in a nebula; he seeks eternity with his love. The stories intersect and parallel;...